CTP Synthetase-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CTP Synthetase-IN-1 是一种有效的、具有口服活性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂，对人 CTPS1 和人 CTPS2 的 IC50 分别为 32 nM 和 18 nM。CTP Synthetase-IN-1 具有抗炎作用。

CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.

CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively.

CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model.Animal Model:Mouse collagen-induced arthritis (CIA) model Dosage:10 mg/kg and 50 mg/kg Administration:p.o; twice daily; for 18 days Result:Resulted in improvements in specific indicators of disease severity.

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Others

Other Targets

Others

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2338811-71-3

512.53

C20H19F3N6O3S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (195.11 mM; 超声助溶 )

O=C(NC1=NC=C(C=C1)C2=NC(=CN=C2)C(F)(F)F)C(C=3N=C(SC3)NS(=O)(=O)C4CC4)(C)C

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(-20℃)

With Ice Pack

≥ 2 years